22-SLF
22-SLF is a PROTAC degrader, that degrades FK506-binding protein 12 (FKBP12) with a DC50 of 0.5 µM. 22-SLF interacts with C227 and C228 in FBXO22 to induce a ternary complex between FKBP12 and FBXO22, and degrades FKBP12 in a FBXO22-dependent manner. 22-SLF can be used for fundamental cancer research as a probe to study the FBXO22 degradation pathway. (Pink: FKBP12 ligand ; Black: Linker (HY-163821) ; Blue: FBXO22 ligand (HY-163826) ).
Product Specifications
UNSPSC
12352005
Target
FKBP; PROTACs
Type
Reference compound
Related Pathways
Apoptosis; Autophagy; Cell Cycle/DNA Damage; Immunology/Inflammation; PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/22-slf.html
Purity
95.72
Smiles
Molecular Formula
C60H76ClN5O13S
Molecular Weight
1142.79
References & Citations
[1]Basu AA, et al., A CRISPR activation screen identifies FBXO22 supporting targeted protein degradation. Nat Chem Biol. 2024 Jul 4.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
FKBP12
Available Sizes
Frequently Asked Questions
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