EGFR-IN-103
EGFR-IN-103 (compound 1) is a potent EGFR inhibitor with an IC50 of 6 nM for pEGFR[1].
Product Specifications
CAS Number
2568506-66-9
UNSPSC
12352005
Target
EGFR
Type
Reference compound
Related Pathways
JAK/STAT Signaling; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/egfr-in-103.html
Solubility
10 mM in DMSO
Smiles
O=C(NC1=NC=CS1)C(N2N=C3C(C(Cl)=CC(C4=CC=C(N5CCOCC5)C=C4)=C3Cl)=C2)C6=C7N(C[C@@H](C7)F)C=N6
Molecular Formula
C28H24Cl2FN7O2S
Molecular Weight
612.51
References & Citations
[1]Ram W. Sabnis. Combination of Allosteric and Orthosteric EGFR Inhibitors for Treating Non-Small-Cell Lung Cancer. ACS Med. Chem. Lett. February 27, 2024.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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