PDD00017238
PDD00017238 is a potent inhibitor of Poly (ADP-ribose) Glycohydrolase (PARG), with EC50 values of 40 nM and 55 nM in biochemical assay and cell POM, respectively[1].
Product Specifications
CAS Number
1952247-05-0
UNSPSC
12352005
Target
Poly (ADP-ribose) Glycohydrolase (PARG)
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/pdd00017238.html
Purity
98.71
Solubility
DMSO : 50 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=S(C1=CC=C(N2CC3=C(C)N=C(C)S3)C(N(C4=NC=NS4)C2=O)=C1)(NC5(C)CC5)=O
Molecular Formula
C19H20N6O3S3
Molecular Weight
476.60
References & Citations
[1]Dominic I James, et al. First-in-Class Chemical Probes against Poly (ADP-ribose) Glycohydrolase (PARG) Inhibit DNA Repair with Differential Pharmacology to Olaparib. ACS Chem Biol. 2016 Nov 18;11 (11) :3179-3190.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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