Fimepinostat (mesylate)
Selected Variant
HY-155890
Size: 1 Each
Fimepinostat mesylate potently inhibits class I PI3Ks as well as classes I and II HDAC enzymes with an IC50 of 19/54/39 nM and 1.7/5.0/1.8/2.8 nM for PI3Kα/PI3Kβ/PI3Kδ and HDAC1/HDAC2/HDAC3/HDAC10 , respectively.
Product Specifications
CAS Number
1401998-36-4
Product Name Alternative
CUDC-907 (mesylate)
UNSPSC
12352005
Target
Apoptosis; HDAC; PI3K
Type
Reference compound
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Epigenetics; PI3K/Akt/mTOR
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/fimepinostat-mesylate.html
Smiles
O=C(C1=CN=C(N(CC2=CC3=NC(C4=CC=C(OC)N=C4)=NC(N5CCOCC5)=C3S2)C)N=C1)NO.CS(=O)(O)=O
Molecular Formula
C24H28N8O7S2
Molecular Weight
604.66
References & Citations
[1]Qian C, et al. Cancer network disruption by a single molecule inhibitor targeting both histone deacetylase activity and phosphatidylinositol 3-kinase signaling. Clin Cancer Res. 2012 Aug 1;18 (15) :4104-13.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 2
Price
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