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Cynaropicrin (Standard)

Cynaropicrin (Standard) is the analytical standard of Cynaropicrin. This product is intended for research and analytical applications. Cynaropicrin is a sesquiterpene lactone which can inhibit tumor necrosis factor (TNF-α) release with IC50s of 8.24 and 3.18 μM for murine and human macrophage cells, respectively. Cynaropicrin also inhibits the increase of cartilage degradation factor (MMP13) and suppresses NF-κB signaling.

Product Specifications

CAS Number

35730-78-0

UNSPSC

12352005

Target

MMP; NF-κB; Reference Standards; TNF Receptor

Type

Reference Standards

Related Pathways

Apoptosis; Metabolic Enzyme/Protease; NF-κB; Others

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/cynaropicrin-standard.html

Smiles

C=C([C@H]1O)[C@]([C@@]2([H])C1)([H])[C@](OC3=O)([H])[C@@](C3=C)([H])[C@@H](OC(C(CO)=C)=O)CC2=C

Molecular Formula

C19H22O6

Molecular Weight

346.37

References & Citations

[1]Cho JY, et al. In vitro anti-inflammatory effects of cynaropicrin, a sesquiterpene lactone, from Saussurea lappa. Eur J Pharmacol. 2000 Jun 23;398 (3) :399-407.|[2]Masutani T, et al. Cynaropicrin is dual regulator for both degradation factors and synthesis factors in the cartilage metabolism. Life Sci. 2016 Aug 1;158:70-7.|[3]da Silva CF, et al. Activities of psilostachyin A and cynaropicrin against Trypanosoma cruzi in vitro and in vivo. Antimicrob Agents Chemother. 2013 Nov;57 (11) :5307-14.

Shipping Conditions

Room temperature

Scientific Category

Reference Standards

Frequently Asked Questions

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