Besigliptin (tosylate)
Besigliptin tosylate (SHR117887) is a DPP-4 inhibitor with activity to improve metabolic control and β-cell function. Besigliptin tosylate can effectively reduce serum DPP-4 activity and improve oral glucose tolerance. Besigliptin tosylate significantly reduces fasting blood glucose levels and improves lipid profiles in a diabetic mouse model. The effect of besigliptin tosylate is comparable to that of the known compound vildagliptin (HY-14291) at the same concentration. Besigliptin tosylate increases insulin staining of pancreatic islet cells in chronic administration, indicating improved β-cell function[1].
Product Specifications
CAS Number
[1177460-72-8]
Product Name Alternative
SHR117887
UNSPSC
12352005
Target
Endogenous Metabolite
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/besigliptin-tosylate.html
Smiles
O=S(O)(C1=CC=C(C=C1)C)=O.O=C(N2[C@@H](C[C@@H](C2)F)C#N)CN[C@@]3(C[C@]4([H])[C@@](C3)([H])CN(C4)C(N(C)C)=O)C
Molecular Formula
C25H36FN5O5S
Molecular Weight
537.65
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 2
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