Besigliptin (tosylate)
Product Specifications
UNSPSC Description
Besigliptin tosylate (SHR117887) is a DPP-4 inhibitor with activity to improve metabolic control and β-cell function. Besigliptin tosylate can effectively reduce serum DPP-4 activity and improve oral glucose tolerance. Besigliptin tosylate significantly reduces fasting blood glucose levels and improves lipid profiles in a diabetic mouse model. The effect of besigliptin tosylate is comparable to that of the known compound vildagliptin (HY-14291) at the same concentration. Besigliptin tosylate increases insulin staining of pancreatic islet cells in chronic administration, indicating improved β-cell function[1].
Target Antigen
Endogenous Metabolite
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/besigliptin-tosylate.html
Smiles
O=S(O)(C1=CC=C(C=C1)C)=O.O=C(N2[C@@H](C[C@@H](C2)F)C#N)CN[C@@]3(C[C@]4([H])[C@@](C3)([H])CN(C4)C(N(C)C)=O)C
Molecular Weight
537.65
References & Citations
[1]Acute and chronic administration of SHR117887, a novel and specific dipeptidyl peptidase-4 inhibitor, improves metabolic control in diabetic rodent models
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-139792/Besigliptin-tosylate-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-139792/
Clinical Information
Phase 2
CAS Number
1177460-72-8
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