3-Cysteinylacetaminophen (trifluoroacetate salt)

<strong>3-Cysteinylacetaminophen (trifluoroacetate salt)</strong>_x000D_ <strong>Catalog number:</strong> B2017553_x000D_ <strong>Lot number:</strong> Batch Dependent_x000D_ <strong>Expiration Date:</strong> Batch dependent_x000D_ <strong>Amount:</strong> 1 mg_x000D_ <strong>Molecular Weight or Concentration:</strong> 384.3_x000D_ <strong>Supplied as:</strong> Powder_x000D_ <strong>Applications:</strong> a molecular tool for various biochemical applications_x000D_ <strong>Storage:</strong> -20°C_x000D_ <strong>Keywords:</strong> 3-(cysteine-S-yl)acetaminophen, APAP-Cys_x000D_ <strong>Grade:</strong> Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity &gt;18 MΩ-cm) and are filtered through 0.22 um._x000D_ _x000D_ <strong>References:</strong>_x000D_ 1: Yang W, Liang Z, Wen C, Jiang X, Wang L. Silymarin Protects against Acute Liver Injury Induced by Acetaminophen by Downregulating the Expression and Activity of the CYP2E1 Enzyme Molecules. 2022 Dec 13;27(24):8855._x000D_ 2: Achterbergh R, Lammers LA, Klümpen HJ, Mathôt RAA, Romijn JA. Short-Term High-Fat Diet Alters Acetaminophen Metabolism in Healthy Individuals Ther Drug Monit. 2022 Dec 1;44(6):797-804._x000D_ 3: Bond GR. Acetaminophen protein adducts: a review Clin Toxicol (Phila). 2009 Jan;47(1):2-7._x000D_ 4: Pumford NR, Hinson JA, Benson RW, Roberts DW. Immunoblot analysis of protein containing 3-(cystein-S-yl)acetaminophen adducts in serum and subcellular liver fractions from acetaminophen-treated mice Toxicol Appl Pharmacol. 1990 Jul;104(3):521-32._x000D_ 5: Szczeklik A, Nizankowska E, Mastalerz L, Szabo Z. Analgesics and asthma Am J Ther. 2002 May-Jun;9(3):233-43._x000D_ 6: Toda A, Shimizu M, Uehara S, Sasaki T, Miura T, Mogi M, Utoh M, Suemizu H, Yamazaki H. Plasma and hepatic concentrations of acetaminophen and its primary conjugates after oral administrations determined in experimental animals and humans and extrapolated by pharmacokinetic modeling Xenobiotica. 2021 Mar;51(3):316-323._x000D_ 7: Dietze EC, Schäfer A, Omichinski JG, Nelson SD. Inactivation of glyceraldehyde-3-phosphate dehydrogenase by a reactive metabolite of acetaminophen and mass spectral characterization of an arylated active site peptide Chem Res Toxicol. 1997 Oct;10(10):1097-103._x000D_ 8: Dargue R, Grant I, Nye LC, Nicholls A, Dare T, Stahl SH, Plumb RS, Lee K, Jalan R, Coen M, Wilson ID. The analysis of acetaminophen (paracetamol) and seven metabolites in rat, pig and human plasma by U(H)PLC-MS Bioanalysis. 2020 Apr;12(7):485-500._x000D_ 9: Hidvegi S, Ecobichon DJ. Acetaminophen in the guinea pig: metabolite identification in blood, urine, and bile Can J Physiol Pharmacol. 1986 Jan;64(1):72-6._x000D_ <a href="https://pubmed.ncbi.nlm.nih.gov/32472168">10: Koenderink JB, van den Heuvel JJMW, Bilos A, Vredenburg G, Vermeulen NPE, Russel FGM. Human multidrug resistance protein 4 (MRP4) is a cellular efflux transporter for paracetamol glutathione and cysteine conjugates Arch Toxicol. 2020 Sep;94(9):3027-3032. </a>_x000D_ _x000D_ <strong>Products Related to 3-Cysteinylacetaminophen (trifluoroacetate salt) can be found at</strong> <a href="https://moleculardepot.com/product-category/Chemicals/"> Chemicals</a>