S9-A13
S9-A13 is a potent and selective inhibitor SLC26A9, with the IC50 of 90.9 nM, without inhibiting other members of the SLC26 family such as SLC26A3, SLC26A4, and SLC26A6. S9-A13 can inhibits SLC26A9 Cl- currents in cells that lack expression of CFTR[1].
Product Specifications
CAS Number
1223771-84-3
UNSPSC
12352005
Target
Chloride Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Applications
Neuroscience-Neuromodulation
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/s9-a13.html
Purity
99.68
Smiles
O=C1NC2=C(C(C1)C(C3=CC=C(C)S3)=O)C(C)=NN2C4=CC=C(C)C(Cl)=C4
Molecular Formula
C20H18ClN3O2S
Molecular Weight
399.89
References & Citations
[1]Sungwoo Jo, et al. The SLC26A9 inhibitor S9-A13 provides no evidence for a role of SLC26A9 in airway chloride secretion but suggests a contribution to regulation of ASL pH and gastric proton secretion. FASEB J. 2022 Nov;36 (11) :e22534.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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