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S9-A13

S9-A13 is a potent and selective inhibitor SLC26A9, with the IC50 of 90.9 nM, without inhibiting other members of the SLC26 family such as SLC26A3, SLC26A4, and SLC26A6. S9-A13 can inhibits SLC26A9 Cl- currents in cells that lack expression of CFTR[1].

Product Specifications

CAS Number

1223771-84-3

UNSPSC

12352005

Target

Chloride Channel

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel

Applications

Neuroscience-Neuromodulation

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/s9-a13.html

Purity

99.68

Smiles

O=C1NC2=C(C(C1)C(C3=CC=C(C)S3)=O)C(C)=NN2C4=CC=C(C)C(Cl)=C4

Molecular Formula

C20H18ClN3O2S

Molecular Weight

399.89

References & Citations

[1]Sungwoo Jo, et al. The SLC26A9 inhibitor S9-A13 provides no evidence for a role of SLC26A9 in airway chloride secretion but suggests a contribution to regulation of ASL pH and gastric proton secretion. FASEB J. 2022 Nov;36 (11) :e22534.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Frequently Asked Questions

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