PTC-028
PTC-028 is an orally bioavailable inhibitor of stem cell factor BMI-1 in ovarian cancer. PTC-028 selectively inhibits cancer cells whereas normal cells remain unaffected. PTC-028 downregulates BMI-1, inducing caspase-mediated apoptosis[1].
Product Specifications
CAS Number
1782970-28-8
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Apoptosis; BMI1
Type
Reference compound
Related Pathways
Apoptosis; Stem Cell/Wnt
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ptc-028.html
Purity
98.0
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
FC(C1=CC=C(NC2=NC(N3C4=CC(F)=C(F)C=C4N=C3C)=CN=C2)C=C1)(F)F
Molecular Formula
C19H12F5N5
Molecular Weight
405.32
Precautions
H302, H315, H319, H335
References & Citations
[1]Dey A, et al. Evaluating the Mechanism and Therapeutic Potential of PTC-028, a Novel Inhibitor of BMI-1 Function in Ovarian Cancer. Mol Cancer Ther. 2018 Jan;17 (1) :39-49.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
IMSAHUCD133W6B3C1CPE100 100 Tests
Anti Human CD133 Flow Cytometry Monoclonal Clone W6B3C1 PE Ready To Use 100 Tests
Sign In for Pricing
View Details 