ENMD-1068 (hydrochloride)

ENMD-1068 hydrochloride is a selective protease-activated receptor 2 (PAR2) antagonist. ENMD-1068 hydrochloride reduces hepatic stellate cell activation and collagen expression by inhibiting TGF-β1/Smad signaling. ENMD-1068 hydrochloride also inhibits the proliferation of endometrial cells and induces apoptosis of epithelial cells in the lesion. ENMD-1068 hydrochloride can be used in the study of endometriosis and liver fibrosis[1][2].

Product Specifications

CAS Number

[2703451-51-6]

UNSPSC

12352005

Hazard Statement

H302

Target

Apoptosis; Protease Activated Receptor (PAR)

Type

Reference compound

Related Pathways

Apoptosis; GPCR/G Protein

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/enmd-1068-hydrochloride.html

Concentration

10mM

Purity

98.33

Solubility

DMSO : 200 mg/mL (ultrasonic) |H2O : 100 mg/mL (ultrasonic)

Smiles

O=C(N1CCN(C(CC(C)C)=O)CC1)CCCCCN.Cl

Molecular Formula

C15H30ClN3O2

Molecular Weight

319.87

Precautions

H302

References & Citations

[1]Sun Q, et al. ENMD-1068 inhibits liver fibrosis through attenuation of TGF-β1/Smad2/3 signaling in mice. Sci Rep. 2017 Jul 14;7 (1) :5498. doi: 10.1038/s41598-017-05190-7. Erratum in: Sci Rep. 2019 Dec 10;9 (1) :19125. |[2]Wang Y, et al. ENMD-1068, a protease-activated receptor 2 antagonist, inhibits the development of endometriosis in a mouse model. Am J Obstet Gynecol. 2014 Jun;210 (6) :531.e1-8.