Glycophorin A / CD235a (A63-B/C2), 0.2mg/mL

Recognizes a sialoglycoprotein of 39 kDa, identified as glycophorin A (GPA) . It is present on red blood cells (RBC) and erythroid precursor cells. It has been shown that glycophorin acts as the receptor for Sandei virus and parvovirus. Glycophorins A (GPA) and B (GPB), which are single, trans-membrane sialoglycoproteins. GPA is the carrier of blood group M and N specificities, while GPB accounts for S and U specificities. GPA and GPB provide the cells with a large mucin like surface and it has been suggested this provides a barrier to cell fusion, so minimizing aggregation between red blood cells in the circulation.This antibody is available purified with BSA/azide at 200 ug/mL, or BSA/azide-free at 1 mg/mL.

Product Specifications

CAS Number

9007-83-4

Synonyms

Blood group--MN locus; GPA; GPErik; GpMiIII; GPSAT; GYPA; MN sialoglycoprotein; MNS; PAS2; Sialoglycoprotein alpha

UNSPSC

41116161

UNSPSC Description

Primary and secondary antibodies for multiple methodology immunostaining detection application

Gene Name

GYPA

Gene ID

2993 & 2994

NCBI Gene ID

434973; 654368

UniProt

P02724

Swiss Prot

P02724

Host

Mouse

Species Reactivity

Human

Reactivity

CD235a|Glycophorin-A

Immunogen

Human erythrocytes treated with neuraminidase

Target Antigen

CD235a | Glycophorin-A

Clonality

Monoclonal

Clone

A63-B/C2

Type

Primary

Source

Animal

Origin

Animal

Field of Research

Hematology

Positive Control

Erythrocytes

Stability

2 years

Concentration

0.2 mg/mL

Buffer

PBS, 0.05% BSA, 0.05% azide

Molecular Weight

39 kDa

References & Citations

Cartron JP and Rahuel C. Human erythrocyte glycophorins: protein and gene structure analyses. Transfus Med Rev 1992,6(2):63-92 | Gahmberg CG et al. Biosynthesis of the major human red cell sialoglycoprotein, glycophorin A. A review. Rev Fr Transfus Immunohematol 1981,24(1):53-73 | Wybenga LE et al. Glycophorin as a receptor for Sendai virus. Biochemistry 1996,35(29):9513-8 | Rahuel C et al. Post-transcriptional regulation of the cell surface expression of glycophorins A, B, and E. J Biol Chem 1994, 269(52):32752-8 | Thacker TC and Johnson FB. Binding of bovine parvovirus to erythrocyte membrane sialylglycoproteins. J Gen Virol 1998, 79:2163-