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Glucose Regulated Protein 94 (GRP94) (9G10.F8.2), 0.2mg/mL

Recognizes a protein of 94 kDa, which is identified as the glucose-regulated protein 94 (grp94) and also tumor rejection antigen (gp96) . Grp94 shows a high degree of sequence homology with the heat shock protein 90 (hsp90) . This MAb is highly specific to grp94 and shows minimal cross-reaction with other members of the HSP90 family. Grp s are a class of proteins unresponsive to heat shock and are induced by glucose deprivation. Grp94 has been briefly studied as a prognostic factor in breast cancer.Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Product Specifications

CAS Number

9007-83-4

Synonyms

Glucose Regulated Protein 94; 94kDa glucose-regulated protein; Endoplasmin; Endothelial cell (HBMEC) glycoprotein (ECGP) ; Heat shock protein 90kDa beta member 1 (HSP90B1) ; Stress inducible tumor rejection antigen GP96; TRA1; Tumor rejection antigen-1 (gp96)

UNSPSC

41116161

UNSPSC Description

Primary and secondary antibodies for multiple methodology immunostaining detection application

Gene Name

HSP90B1

Gene ID

7184

NCBI Gene ID

192374

UniProt

P14625

Swiss Prot

P14625

Host

Rat

Species Reactivity

Chicken,Cow,Dog,Guinea pig,Hamster,Horse,Human,Monkey,Mouse,Pig,Rabbit,Rat,Sheep,Xenopus

Reactivity

Glucose Regulated Protein 94

Immunogen

Purified glucose regulated protein 94 (grp94) from chicken oviducts

Target Antigen

Glucose Regulated Protein 94

Clonality

Monoclonal

Clone

9G10.F8.2

Type

Primary

Source

Animal

Origin

Animal

Applications

Flow, intracellular (verified) |IF (verified) |IHC, FFPE (verified)

Field of Research

Cancer, Chaperones, Metabolism

Positive Control

U20S cells. About 50% of breast tumors express grp94 protein

Stability

2 years

Concentration

0.2 mg/mL

Buffer

PBS, 0.05% BSA, 0.05% azide

Molecular Weight

94 kDa

Shipping Conditions

RT (ND)

Storage Conditions

Stable at room temperature or 37°C (98°F) for 7 days.

Shelf Life

Guaranteed for at least 24 months from date of receipt when stored as recommended

Fragment

IgG2a, kappa

Species

Rattus norvegicus (laboratory rat), BSA from bovine serum (Bos taurus) or recombinant BSA produced in Chinese hamster ovary cells.

Classification

PBS, 0.05% BSA, 0.05% sodium azide (CAS 26628-22-8)

Conjugate

Purified, with BSA

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