Rabbit anti Human Lass4
Product Specifications
Background
It is thought that Lass4 may be either a bona fide (dihydro)ceramide synthase or a modulator of its activity. When overexpressed in cells is involved in the production of sphingolipids containing different fatty acid donnors (N-linked stearoyl- (C18) or arachidoyl- (C20) ceramides) in a fumonisin B1-independent manner.
CAS Number
9007-83-4
UniProt
Q9HA82
Host
Rabbit
Species Reactivity
Human
Isotype
IgG
Conjugation
Affinity Purified
Type
Antigen Immunoaffinity Purified Polyclonal
Source
Rabbits were immunized with a synthetic peptide derived from Human Lass4 protein.
Applications
WB
Field of Research
Cell Biology
Purification Method
Antigen Immunoaffiinity Purification
Assay Principle
Antibody can be used for Western blotting (1:400 starting dilution). Optimal concentration should be evaluated by serial dilutions.
Stability
See expiration date on vial
Concentration
Lot specific, See vial
Form
Provided as solution in phosphate buffered saline with 0,08% sodium azide
Precautions
This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving Humans or animals.
References & Citations
1. Min, J., et al. '(Dihydro)ceramide synthase 1 regulated sensitivity to cisplatin is associated with the activation of p38 mitogen-activated protein kinase and is abrogated by sphingosine kinase 1.' Mol. Cancer Res. 2007, 5(8):801-812_x000D_
2. Ruckhaberle, E., et al. 'Microarray analysis of altered sphingolipid metabolism reveals prognostic significance of sphingosine kinase 1 in breast cancer.' Breast Cancer Res Treat. 2007 Dec 4 [Epub ahead of print]
Shipping Conditions
Ambient Temperature, freeze upon arrival
Storage Conditions
Product should be stored at -20ºC; Aliquot to avoid freeze/thaw cycles
Functional Analysis
WB
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