Rabbit anti Human Lass4

Product Specifications

Background

It is thought that Lass4 may be either a bona fide (dihydro)ceramide synthase or a modulator of its activity. When overexpressed in cells is involved in the production of sphingolipids containing different fatty acid donnors (N-linked stearoyl- (C18) or arachidoyl- (C20) ceramides) in a fumonisin B1-independent manner.

CAS Number

9007-83-4

UniProt

Q9HA82

Host

Rabbit

Species Reactivity

Human

Isotype

IgG

Conjugation

Affinity Purified

Type

Antigen Immunoaffinity Purified Polyclonal

Source

Rabbits were immunized with a synthetic peptide derived from Human Lass4 protein.

Applications

Field of Research

Cell Biology

Purification Method

Antigen Immunoaffiinity Purification

Assay Principle

Antibody can be used for Western blotting (1:400 starting dilution). Optimal concentration should be evaluated by serial dilutions.

Stability

See expiration date on vial

Concentration

Lot specific, See vial

Form

Provided as solution in phosphate buffered saline with 0,08% sodium azide

Precautions

This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving Humans or animals.

References & Citations

1. Min, J., et al. '(Dihydro)ceramide synthase 1 regulated sensitivity to cisplatin is associated with the activation of p38 mitogen-activated protein kinase and is abrogated by sphingosine kinase 1.' Mol. Cancer Res. 2007, 5(8):801-812_x000D_ 2. Ruckhaberle, E., et al. 'Microarray analysis of altered sphingolipid metabolism reveals prognostic significance of sphingosine kinase 1 in breast cancer.' Breast Cancer Res Treat. 2007 Dec 4 [Epub ahead of print]