Cap-dependent endonuclease-IN-28
Cap-dependent endonuclease-IN-28 (Compound 11) is a potent cap-dependent endonuclease (CEN) inhibitor. Cap-dependent endonuclease-IN-28 inhibits CEN of TOSV, ANDV, and LACV viruses with IC50 values of 2.4, 0.5, and 4 μM, respectively[1].
Product Specifications
UNSPSC
12352005
Target
Influenza Virus
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-anti-virus
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/cap-dependent-endonuclease-in-28.html
Smiles
O=C1N(CC2=CC=C(O)C(O)=C2)CC3=C1C(O)=C(O)C=C3
Molecular Formula
C15H13NO5
Molecular Weight
287.27
References & Citations
[1]Miglioli F, et al. Inhibitory interactions of the 2,3-dihydro-6,7-dihydroxy-1H-isoindol-1-one scaffold with Bunyavirales cap-snatching endonucleases expose relevant drug design features. Eur J Med Chem. 2024 Jun 5;272:116467.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
BNC680226-500 1x 500 µL
Pmel17 / gp100 / SILV (NKI-beteb), CF568 conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
BNC400253-100 1x 100 µL
Cytokeratin, LMW (AE-1), CF640R conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
BNC470017-500 1x 500 µL
Ep-CAM / CD326 (VU-1D9), CF647 conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
BNC882375-100 1x 100 µL
Cytokeratin 14 (KRT14) (Squamous Cell Marker) (KRT14/2375), CF488A conjugate, 0.1mg/mL
Sign In for Pricing
View Details