(S, R, S) -AHPC-PEG2-C4-Cl
(S, R, S) -AHPC-PEG2-C4-Cl (VH032-PEG2-C4-Cl) is a conjugate of ligands for E3 and 13-atom-length linker. The connector of linker is Halogen group. (S, R, S) -AHPC-PEG2-C4-Cl incorporates the (S, R, S) -AHPC based VHL ligand and an alkyl/ether-based linker. (S, R, S) -AHPC-PEG2-C4-Cl is capable of inducing the degradation of GFP-HaloTag7 in cell-based assays[1].
Product Specifications
CAS Number
[1835705-57-1]
Product Name Alternative
VH032-PEG2-C4-Cl; VHL Ligand-Linker Conjugates 7; E3 ligase Ligand-Linker Conjugates 10
UNSPSC
12352005
Hazard Statement
H302-H315-H319-H335
Target
E3 Ligase Ligand-Linker Conjugates
Type
Reference compound
Related Pathways
PROTAC
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/E3 ligase_Ligand-Linker_Conjugates_10.html
Purity
98.21
Solubility
DMSO : ≥ 50 mg/mL|Ethanol : 50 mg/mL (ultrasonic) |H2O : 50 mg/mL (ultrasonic)
Smiles
O=C([C@H]1N(C([C@H](C(C)(C)C)NC(COCCOCCCCCCCl)=O)=O)C[C@H](O)C1)NCC2=CC=C(C3=C(C)N=CS3)C=C2
Molecular Formula
C32H47ClN4O6S
Molecular Weight
651.26
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Von Hippel-Lindau (VHL)
Available Sizes
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