(S,R,S)-AHPC-PEG2-C4-Cl
Product Specifications
UNSPSC Description
(S,R,S)-AHPC-PEG2-C4-Cl (VH032-PEG2-C4-Cl) is a conjugate of ligands for E3 and 13-atom-length linker. The connector of linker is Halogen group. (S,R,S)-AHPC-PEG2-C4-Cl incorporates the (S,R,S)-AHPC based VHL ligand and an alkyl/ether-based linker. (S,R,S)-AHPC-PEG2-C4-Cl is capable of inducing the degradation of GFP-HaloTag7 in cell-based assays[1].
Target Antigen
E3 Ligase Ligand-Linker Conjugates
Type
Reference compound
Related Pathways
PROTAC
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/E3 ligase_Ligand-Linker_Conjugates_10.html
Purity
98.21
Solubility
DMSO : ≥ 50 mg/mL|Ethanol : 50 mg/mL (ultrasonic)|H2O : 50 mg/mL (ultrasonic)
Smiles
O=C([C@H]1N(C([C@H](C(C)(C)C)NC(COCCOCCCCCCCl)=O)=O)C[C@H](O)C1)NCC2=CC=C(C3=C(C)N=CS3)C=C2
Molecular Weight
651.26
References & Citations
[1]Craig Crews, et al. Proteolysis Targeting Chimera Compounds and Methods of Preparing and Using Same. US20170121321A1.|[2]Lai AC, et al. Modular PROTAC Design for the Degradation of Oncogenic BCR-ABL. Angew Chem Int Ed Engl. 2016 Jan 11;55(2):807-10.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-103607/S-R-S-AHPC-PEG2-C4-Cl-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-103607/S-R-S-AHPC-PEG2-C4-Cl-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
1835705-57-1
Available Sizes
Curated Selection
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