PDE3B-IN-1

PDE3B-IN-1 is a selective inhibitor for phosphodiesterase PDE3B with an IMAP pIC50 of 6.5 and a PDE3B/A selective index >300[1].

Product Specifications

CAS Number

[3032458-01-5]

UNSPSC

12352005

Target

Phosphodiesterase (PDE)

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/pde3b-in-1.html

Solubility

10 mM in DMSO

Smiles

O=C(C1=CC(NC(C2=NC3=CC(OC)=CC=C3C(OC)=C2)=O)=CC(B(O)O)=C1)NC(C)COC

Molecular Formula

C23H26BN3O7

Molecular Weight

467.28

References & Citations

[1]Rowley AM, et al., Discovery and SAR Study of Boronic Acid-Based Selective PDE3B Inhibitors from a Novel DNA-Encoded Library. J Med Chem. 2024 Feb 8;67 (3) :2049-2065.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

PDE3

Available Sizes

Curated Selection

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