5-HT2A antagonist 2

5HT2A antagonist 2 is an orally active, selective antagonist for 5HT2A with IC50 of 14 nM. 5-HT2A antagonist 2 exhibits good chemical, hepatocyte, and plasma stability, without significant cytotoxicity in cell lines VERO, HFL-1, L929, NIH3T3, CHO-K1[1].

Product Specifications

CAS Number

[2641482-08-6]

UNSPSC

12352005

Target

5-HT Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/5-ht2a-antagonist-2.html

Purity

98.90

Solubility

10 mM in DMSO

Smiles

CC1=C(CCN2CC/C(CC2)=C3C(C=CC(Cl)=C4)=C4CCC5=CC=CN=C5\3)C(N(CCCC6O)C6=N1)=O

Molecular Formula

C30H33ClN4O2

Molecular Weight

517.06

References & Citations

[1]Pagire HS, et al., Discovery of a peripheral 5HT2A antagonist as a clinical candidate for metabolic dysfunction-associated steatohepatitis. Nat Commun. 2024 Jan 20;15 (1) :645.