5-HT2A antagonist 2
5HT2A antagonist 2 is an orally active, selective antagonist for 5HT2A with IC50 of 14 nM. 5-HT2A antagonist 2 exhibits good chemical, hepatocyte, and plasma stability, without significant cytotoxicity in cell lines VERO, HFL-1, L929, NIH3T3, CHO-K1[1].
Product Specifications
CAS Number
2641482-08-6
UNSPSC
12352005
Target
5-HT Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/5-ht2a-antagonist-2.html
Purity
98.90
Solubility
10 mM in DMSO
Smiles
CC1=C(CCN2CC/C(CC2)=C3C(C=CC(Cl)=C4)=C4CCC5=CC=CN=C5\3)C(N(CCCC6O)C6=N1)=O
Molecular Formula
C30H33ClN4O2
Molecular Weight
517.06
References & Citations
[1]Pagire HS, et al., Discovery of a peripheral 5HT2A antagonist as a clinical candidate for metabolic dysfunction-associated steatohepatitis. Nat Commun. 2024 Jan 20;15 (1) :645.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
5-HT2 Receptor; α-1 microglobulin
Available Sizes
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