Anti-Neuroligin-3 Antibody

Mouse Monoclonal Antibody specific to Neuroligin-3

Product Specifications

CAS Number

9007-83-4

Product Name Alternative

Gliotactin homolog

Gene Name

Nlgn3

NCBI Gene ID

UniProt

Q62889

Cellular Locus

Cell membrane; Single-pass type I membrane protein. Cell junction, synapse. Note=Detected at both glutamatergic and GABAergic synapses.

Host

Mouse

Reactivity

Human, Mouse, Rat

Immunogen

Fusion protein corresponding to aa 730-848 (intracellular C-terminus) of rat Neuroligin- 3. This sequence is 99

Target Antigen

Neuroligin-3

Target

Neuroligin-3

Clonality

Monoclonal

Isotype

IgG1

Type

Antibody

Applications

WB, IHC, ICC/IF

Field of Research

Neuroscience

Purification Method

Purified by Protein G affinity chromatography

Concentration

1.0 mg/mL

Dilution

Dilute in PBS or medium that is identical to that used in the assay system.

Format

Purified

Form

Liquid

Buffer

Phosphate Buffered Saline

Function

Cell surface protein involved in cell-cell-interactions via its interactions with neurexin family members. Plays a role in synapse function and synaptic signal transmission, and probably mediates its effects by recruiting and clustering other synaptic proteins. May promote the initial formation of synapses, but is not essential for this. May also play a role in glia-glia or glia-neuron interactions in the developing peripheral nervous system. {PubMed:17897391}.

Additionnal Information

Immunoblotting: use at 1-5ug/mL. A band of ~110kDa is detected. Immunofluorescence: use at 10ug/mL. These are recommended concentrations. Endusers should determine optimal concentrations for their application.

Storage Conditions

This product is stable for at least one (1) year at -20°C.

Specificity

This antibody recognizes human, mouse and rat Neuroligin-3. It does not cross- react with Neuroligin-1, -2, or -4.

Formulation

PBS, pH 7.4, 0.1% sodium azide, 50% glycerol.

Buffer pH

pH 7.4

Target Background

Neuroligin-3 is a neuronal cell surface protein involved in cell-cell-interactions via its interactions with neurexin family members. It plays a role in synapse function and synaptic signal transmission, and may mediate its effects by clustering other synaptic proteins. It may also promote the initial formation of synapses and play a role in glia-glia or glia-neuron interactions in the developing peripheral nervous system. Mutations in this gene may be associated with autism and Asperger syndrome. Multiple transcript variants encoding distinct isoforms have been identified for this gene.

Curated Selection

Explore Other Products

Discover premium biology products from our extensive collection of 20M+ items

MBS1373048-01 0.02 mg (E-Coli)

Recombinant Mycobacterium bovis UDP-N-acetylmuramoylalanine--D-glutamate ligase (murD)

Ask

View Details

MBS1373048-02 0.02 mg (Yeast)

Recombinant Mycobacterium bovis UDP-N-acetylmuramoylalanine--D-glutamate ligase (murD)

Ask

View Details

MBS1373048-03 0.1 mg (E-Coli)

Recombinant Mycobacterium bovis UDP-N-acetylmuramoylalanine--D-glutamate ligase (murD)

Ask

View Details

MBS1373048-04 0.1 mg (Yeast)

Recombinant Mycobacterium bovis UDP-N-acetylmuramoylalanine--D-glutamate ligase (murD)

Ask

View Details

MBS1373048-05 0.02 mg (Baculovirus)

Recombinant Mycobacterium bovis UDP-N-acetylmuramoylalanine--D-glutamate ligase (murD)

Ask

View Details

MBS1373048-06 0.02 mg (Mammalian-Cell)

Recombinant Mycobacterium bovis UDP-N-acetylmuramoylalanine--D-glutamate ligase (murD)

Ask

View Details