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SDH-IN-2

SDH-IN-2 is a potent succinate dehydrogenase (SDH) inhibitor with an IC50 of 0.55 μg/mL. SDH-IN-2 is also an antifungal agent. SDH-IN-2 inhibits phytopathogenic fungia with average EC50 values of 3.82-9.81 μg/mL for all the fungi[1]. SDH-IN-2 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

Product Specifications

CAS Number

[1823354-06-8]

UNSPSC

12352005

Target

Fungal

Type

Reference compound

Related Pathways

Anti-infection

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/sdh-in-2.html

Purity

99.85

Solubility

DMSO : 250 mg/mL (ultrasonic)

Smiles

O=C(NC1=CC=C(C(F)(F)F)C=C1)C#C

Molecular Formula

C10H6F3NO

Molecular Weight

213.16

References & Citations

[1]Zhang YH, et al. Discovery of N-Phenylpropiolamide as a Novel Succinate Dehydrogenase Inhibitor Scaffold with Broad-Spectrum Antifungal Activity on Phytopathogenic Fungi. J Agric Food Chem. 2023 Mar 1;71 (8) :3681-3693.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Curated Selection

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