2-Aminopurine

2-Aminopurine, a fluorescent analog of guanosine and adenosine, is a widely used fluorescence-decay-based probe of DNA structure. When 2-Aminopurine is inserted in anoligonucleotide, its fluorescence is highly quenched by stacking with the natural bases. 2-Aminopurine has been used to probe nucleic acid structure and dynamics[1][2].

Product Specifications

CAS Number

[452-06-2]

UNSPSC

12171500

Hazard Statement

H302

Target

DNA Stain

Type

Dye Reagents

Related Pathways

Cell Cycle/DNA Damage

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/2-aminopurine.html

Purity

99.61

Solubility

DMSO : 5 mg/mL (ultrasonic) |H2O : 1.35 mg/mL (ultrasonic)

Smiles

NC1=NC=C2NC=NC2=N1

Molecular Formula

C5H5N5

Molecular Weight

135.13

Precautions

H302

References & Citations

[1]J M Jean, et al. 2-Aminopurine fluorescence quenching and lifetimes: role of base stacking. Proc Natl Acad Sci U S A. 2001 Jan 2;98 (1) :37-41.|[2]Dehong Tan, et al. Decreased glycation and structural protection properties of γ-glutamyl-S-allyl-cysteine peptide isolated from fresh garlic scales (Allium sativum L.) . Nat Prod Res. 2015;29 (23) :2219-22.