What is the catalog number for Anti-DLL4 APC?

The catalog number for Anti-DLL4 APC is 1A-717-C100.

What sizes are available for Anti-DLL4 APC?

Anti-DLL4 APC is available in the following size(s): 0.1 mg.

Is Anti-DLL4 APC in stock?

Anti-DLL4 APC is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures Anti-DLL4 APC?

Anti-DLL4 APC is manufactured by AFG-XBO.

What is the estimated delivery time for Anti-DLL4 APC?

Estimated delivery time for Anti-DLL4 APC is approximately 10 business day(s), depending on your location.

Anti-DLL4 APC

DLL4 (Delta-like 4) is one of five ligands of Notch receptors. It is up-regulated at sites of physiological and pathological angiogenesis, whereas its expression is low in most adult normal tissues. It is also highly expressed in human clear-cell renal carcinomas, bladder cancers, and breast cancers. Blocking the DLL4-Notch interaction seems to be a promissing therapeutic approach.

Product Specifications

Certification

RUO

Reactivity

Human

Immunogen

Recombinant soluble human DLL4

Target Antigen

DLL4

Clone

MHD4-46

Applications

FC (QC tested)

Concentration

0.1 mg/mL

Format

APC

Buffer

Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

References & Citations

*Yamanda S, Ebihara S, Asada M, Okazaki T, Niu K, Ebihara T, Koyanagi A, Yamaguchi N, Yagita H, Arai H: Role of ephrinB2 in nonproductive angiogenesis induced by Delta-like 4 blockade. Blood. 2009 Apr 9;113 (15) :3631-9, URL: http://www.ncbi.nlm.nih.gov/pubmed/19218547, *Oishi H, Sunamura M, Egawa S, Motoi F, Unno M, Furukawa T, Habib NA, Yagita H: Blockade of delta-like ligand 4 signaling inhibits both growth and angiogenesis of pancreatic cancer. Pancreas. 2010 Aug;39 (6) :897-903, URL: http://www.ncbi.nlm.nih.gov/pubmed/?term=oishi+h+sunamura+m , *Sekine C, Koyanagi A, Koyama N, Hozumi K, Chiba S, Yagita H: Differential regulation of osteoclastogenesis by Notch2/Delta-like 1 and Notch1/Jagged1 axes. Arthritis Res Ther. 2012 Mar 5;14 (2) :R45., URL: http://www.ncbi.nlm.nih.gov/pubmed/22390640

Storage Conditions

Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.

Specificity

The mouse monoclonal antibody MHD4-46 recognizes the extracellular domain of DLL4 (Delta-like ligand 4), a type I transmembrane protein which plays an important role in vascular development.