Anti-DLL4 APC
DLL4 (Delta-like 4) is one of five ligands of Notch receptors. It is up-regulated at sites of physiological and pathological angiogenesis, whereas its expression is low in most adult normal tissues. It is also highly expressed in human clear-cell renal carcinomas, bladder cancers, and breast cancers. Blocking the DLL4-Notch interaction seems to be a promissing therapeutic approach.
Product Specifications
Certification
RUO
Reactivity
Human
Immunogen
Recombinant soluble human DLL4
Target Antigen
DLL4
Clone
MHD4-46
Applications
FC (QC tested)
Concentration
0.1 mg/mL
Format
APC
Buffer
Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
References & Citations
*Yamanda S, Ebihara S, Asada M, Okazaki T, Niu K, Ebihara T, Koyanagi A, Yamaguchi N, Yagita H, Arai H: Role of ephrinB2 in nonproductive angiogenesis induced by Delta-like 4 blockade. Blood. 2009 Apr 9;113 (15) :3631-9, URL: http://www.ncbi.nlm.nih.gov/pubmed/19218547, *Oishi H, Sunamura M, Egawa S, Motoi F, Unno M, Furukawa T, Habib NA, Yagita H: Blockade of delta-like ligand 4 signaling inhibits both growth and angiogenesis of pancreatic cancer. Pancreas. 2010 Aug;39 (6) :897-903, URL: http://www.ncbi.nlm.nih.gov/pubmed/?term=oishi+h+sunamura+m , *Sekine C, Koyanagi A, Koyama N, Hozumi K, Chiba S, Yagita H: Differential regulation of osteoclastogenesis by Notch2/Delta-like 1 and Notch1/Jagged1 axes. Arthritis Res Ther. 2012 Mar 5;14 (2) :R45., URL: http://www.ncbi.nlm.nih.gov/pubmed/22390640
Storage Conditions
Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.
Specificity
The mouse monoclonal antibody MHD4-46 recognizes the extracellular domain of DLL4 (Delta-like ligand 4), a type I transmembrane protein which plays an important role in vascular development.
Applications Notes
Flow cytometry: Recommended dilution: 1-5 μg/ml.
Isotype
Mouse IgG1 kappa
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