GSK805

GSK805 is an orally active and CNS penetrant RORγt inhibitor. GSK805 inhibits RORγ and Th17 cells differentiation with pIC50 values of 8.4 and >8.2. GSK805 inhibits the function of Th17 cells. GSK805 can be used for the research of immunity[1].

Product Specifications

CAS Number

[1426802-50-7]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

ROR

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/ROR-gamma-t-IN-1.html

Purity

98.01

Solubility

DMSO : ≥ 100 mg/mL

Smiles

O=C(NC1=CC(Cl)=C(C2=CC=CC=C2OC(F)(F)F)C(Cl)=C1)CC3=CC=C(S(=O)(CC)=O)C=C3

Molecular Formula

C23H18Cl2F3NO4S

Molecular Weight

532.36

Precautions

H302, H315, H319, H335

References & Citations

[1]Wang Y, et al. Discovery of Biaryl Amides as Potent, Orally Bioavailable, and CNS Penetrant RORγt Inhibitors. ACS Med Chem Lett. 2015 May 26;6 (7) :787-792.|[2]Xiao S, et al. Small-molecule RORγt antagonists inhibit T helper 17 cell transcriptional network by divergent mechanisms. Immunity. 2014 Apr 17;40 (4) :477-89.