Human Haptoglobin Protein, His tag
Haptoglobin is a glycoprotein, which is synthesized in the liver and circulates in the blood. Haptoglobin is usually produced by liver cells, but it is also produced by other tissues, such as skin, lung and kidney. It is a positive acute phase protein, which binds to free hemoglobin and removes it from circulation to prevent kidney injury and iron loss after hemolysis. Decreased levels can be seen in hemolysis and impaired liver function. A high level is a sign of acute or chronic inflammation. Hemoglobin deficiency or hypohaptoglobinemia is caused by mutation of haptoglobin gene and/or its regulatory region. Haptoglobin is also related to diabetic nephropathy, the incidence of coronary artery disease in type 1 diabetes, Crohn's disease, inflammatory disease behavior, susceptibility to primary sclerosing cholangitis, idiopathic Parkinson's disease and the reduction of the incidence of plasmodium falciparum malaria.
Product Specifications
Background
Product Name Alternative
Haptoglobin
Gene ID
3240
Accession Number
P00738
Tag
Haptoglobin
Type
Cytokines and proteins
Applications
His tag
Purity
> 95 % as determined by SDS-PAGE
Activity
Testing in progress
Molecular Weight
29.5 kDa
Precautions
Features & Benefits
Endotoxin: < 0.1 EU per μg of the protein as determined by the LAL method.
Shipping Conditions
Gel pack with blue ice.
Storage Conditions
Protein Length
The recombinant Human Haptoglobin consists of 245 amino acids and predicts a molecular mass of 29.5 kDa.
Formulation
Lyophilized from sterile PBS, pH 7.4.
Applications Notes
Human
Other Product Names
Haptoglobin
Recommended Usage
Preparation
E. coli
Accession Number URL
https://www.uniprot.org/uniprotkb/P00738
AA Sequence
Amino acid sequence derived from Human Haptoglobin (AAA88080.1) (Ile162-Asn406) was expressed with 6xHis tag at N-terminus.
Available Sizes
Frequently Asked Questions
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