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Nab-Paclitaxel

Nab-Paclitaxel (Nanoparticle albumin-bound Paclitaxel) is an albumin-bound nanoparticle formulation of Paclitaxel (HY-B0015) . Nab-Paclitaxel is composed of albumin and the active pharmaceutical ingredient Paclitaxel, in which human albumin is used as an excipient to disperse and stabilize particles and carry the main drug. Nab-Paclitaxel is a solvent-free taxane with higher response rates and improved tolerability. Nab-Paclitaxel displays less toxicity and greater antitumor activity. Nab-Paclitaxel is more readily available for tumor cell uptake in three rhabdomyosarcoma, seven neuroblastoma cell lines, and one ostersarcoma cell line Nab-Paclitaxel can be studied in cancer research for example breast cancer and solid tumors. (The product specifications below only indicate the effective content of Paditaxel, the actual albumin quality depends on the batch; the ratio of each ingredient in this product is Paditaxel: albumin -1:7~1:11) [1][2].

Product Specifications

Product Name Alternative

Nanoparticle albumin-bound Paclitaxel; Nanoparticle albumin-bound ABI-007

UNSPSC

12352203

Hazard Statement

H341, H351, H360, H372

Target

Apoptosis; Autophagy; Microtubule/Tubulin

Type

Inhibitory Antibodies

Related Pathways

Apoptosis; Autophagy; Cell Cycle/DNA Damage; Cytoskeleton

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/nab-paclitaxel.html

Purity

99.9

Solubility

H2O : < 0.1 mg/mL (ultrasonic)

Smiles

[Nab-Paclitaxel]

Precautions

H341, H351, H360, H372

References & Citations

[1]Yardley DA. nab-Paclitaxel mechanisms of action and delivery. J Control Release. 2013 Sep 28;170 (3) :365-72.|[2]Yamamoto, Y., et al., (2011) . Nab-paclitaxel for the treatment of breast cancer: efficacy, safety, and approval. OncoTargets and therapy, 4, 123–136.|[3]Zhang, L., Marrano, P., et al., (2013) . Nab-paclitaxel is an active drug in preclinical model of pediatric solid tumors. Clinical cancer research : an official journal of the American Association for Cancer Research, 19 (21), 5972–5983.

Shipping Conditions

Blue Ice

Storage Conditions

Store at 4°C for 2 years, do not freeze

Scientific Category

Inhibitory Antibodies

Clinical Information

Phase 4

Available Sizes

Curated Selection

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