KRASG12C IN-14
KRASG12C IN-14 (compound 15) is an inhibitor targeting the KRAS G12C mutation. KRASG12C IN-14 inhibits CYPA-dependent KRAS-BRAF with an IC50 of 0.002 μM. KRASG12C IN-14 inhibits ERK phosphorylation in NCI-H358 cells with an IC50 of 0.002 μM[1].
Product Specifications
UNSPSC
12352005
Target
Ras
Type
Reference compound
Related Pathways
GPCR/G Protein; MAPK/ERK Pathway
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/krasg12c-in-14.html
Smiles
O=C(OCC(C)(C)CC1=[C@@]([C@@]2=C([C@@H](OC)C)N=CC(N3CCOCC3)=C2)N(CC(F)(F)F)C4=C1C=C5C=C4)[C@H]6NN(C([C@@H](NC([C@H](C(C)C)N(C(N7CC(/C=C(S(C)(=O)=O)\F)C7)=O)C)=O)CC8=NC5=CS8)=O)CCC6
Molecular Formula
C51H65F4N9O9S2
Molecular Weight
1088.24
References & Citations
[1]Jianguo Chen, et al. Sulfonylvinyl compounds for the treatment of cancer. WO2024149819A1. 2024-01-11
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
K-Ras
Frequently Asked Questions
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