Rabbit anti Human Calcium Channel subunit alpha-1I

Product Specifications

Background

Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. T-type channels serve pacemaking functions in both central neurons and cardiac nodal cells and support calcium signaling in secretory cells and vascular smooth muscle. They may also be involved in the modulation of firing patterns of neurons which is important for information processing as well as in cell growth processes. Using co-transfection techniques we investigated the functional effects of each of the gamma subunits on the biophysics of the T-type VSCC encoded by the alpha(1I) subunit. This revealed a substantially slowed rate of deactivation in the presence of gamma(2). In contrast, there was no significant corresponding effect of either gamma(3) or gamma(4) on alpha(1I) subunit-mediated currents.(2)

CAS Number

9007-83-4

Synonyms

Voltage-gated calcium channel subunit alpha Cav3.3,

UniProt

Q9P0X4

Host

Rabbit

Species Reactivity

Human

Isotype

IgG

Conjugation

Unconjugated

Type

Polyclonal Antibody

Source

Rabbits were immunized with a synthetic peptide derived from the rat alpha1 calcium channel conjugated to KLH

Applications

Field of Research

Signal Transduction

Purification Method

Ammonium Sulfate Precipitation

Assay Principle

This antibody can be used for Western blotting (5-10 µg/mL). Optimal concentration should be evaluated by serial dilutions.

Stability

See expiration date on vial

Concentration

See vial for Concentration

Form

Provided as solution in phosphate buffered saline with 0,08% sodium azide

Precautions

This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving Humans or animals.

References & Citations

1. McRory, J.E. et al 'Molecular and functional characterization of a family of rat brain T-type calcium channels.' J. Biol. Chem. 276 (6), 3999-4011 (2001)._x000D_ 2. Green, P.J., et al.Kinetic modification of the alpha(1I) subunit-mediated T-type Ca(2+) channel by a Human neuronal Ca(2+) channel gamma subunit.' J. Physiol. 533(Pt 2):467-78.(2001)