(R) - (+) -O-Demethylbuchenavianine
(R) - (+) -O-Demethylbuchenavianine is an inhibitor for Cyclin-dependent kinases (CDK) . (R) - (+) -O-Demethylbuchenavianine inhibits CDK1, CDK5, glycogen synthase kinase-3 (GSK3), cdc2-like kinase (CLK1) and dual specificity tyrosine-phosphorylation-regulated kinase 1A (DYRK1A), with IC50s of 1.1, 0.95, >10, >10 and >10 μM, respectively[1].
Product Specifications
CAS Number
[1364123-68-1]
UNSPSC
12352005
Target
CDK; DYRK; GSK-3
Type
Natural Products
Related Pathways
Cell Cycle/DNA Damage; PI3K/Akt/mTOR; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/r-plus-o-demethylbuchenavianine.html
Purity
98.67
Smiles
OC1=CC(O)=C(C(C=C(C2=CC=CC=C2)O3)=O)C3=C1[C@@H]4N(CCCC4)C
Molecular Formula
C21H21NO4
Molecular Weight
351.40
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
CDK1; CDK5; CLK; DYRK1; GSK-3
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