[D-Leu-4]-OB3

[D-Leu-4]-OB3 inhibits expressions of pro-inflammatory, proliferative and metastatic genes and PD-L1 expression. [D-Leu-4]-OB3 stimulates expression of pro-apoptotic genes[1].

Product Specifications

CAS Number

[289056-32-2]

UNSPSC

12352209

Target

Apoptosis; PD-1/PD-L1

Type

Peptides

Related Pathways

Apoptosis; Immunology/Inflammation

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/d-leu-4-ob3.html

Purity

98.93

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

C[C@@H](O)[C@@H](C(O)=O)NC([C@H](CCC(N)=O)NC([C@H]1N(CCC1)C([C@@H](CC(C)C)NC([C@H](CO)NC([C@H](CS)NC([C@@H](N)CO)=O)=O)=O)=O)=O)=O

Molecular Formula

C29H50N8O12S

Molecular Weight

734.82

References & Citations

[1]Yih Ho, et al. Leptin-derived peptides block leptin-induced proliferation by reducing expression of pro-inflammatory genes in hepatocellular carcinoma cells.Food Chem Toxicol. 2019 Nov;133:110808.