NSC-207895
NSC-207895 (XI-006), a DNA damaging agent, is an anticancer agent and p53 activator[1][2][3].
Product Specifications
CAS Number
58131-57-0
Product Name Alternative
XI-006
UNSPSC
12352005
Hazard Statement
H228, H315, H319
Target
MDM-2/p53
Type
Reference compound
Related Pathways
Apoptosis
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/nsc-207895.html
Purity
98.85
Solubility
DMSO : 31.25 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=[N+](C1=CC=C(N2CCN(C)CC2)C3=[N+]([O-])ON=C31)[O-]
Molecular Formula
C11H13N5O4
Molecular Weight
279.25
Precautions
H228, H315, H319
References & Citations
[1]Laura Kapitzky, et al. Cross-species chemogenomic profiling reveals evolutionarily conserved drug mode of action. Mol Syst Biol. 2010 Dec 21;6:451.|[2]Erdenezaya Odkhuu, et al. Lipopolysaccharide downregulates the expression of p53 through activation of MDM2 and enhances activation of nuclear factor-kappa B. Immunobiology. 2015 Jan;220 (1) :136-41.|[3]Luis A Carvajal, et al. Dual inhibition of MDMX and MDM2 as a therapeutic strategy in leukemia. Sci Transl Med. 2018 Apr 11;10 (436) :eaao3003.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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