AKT-IN-6
AKT-IN-6 (Example 13) is a potent Akt inhibitor. AKT-IN-6 inhibits Akt1, Akt2 and Akt3 with IC50s < 500nM, respectively. (patent WO2013056015A1) .
Product Specifications
CAS Number
[1430056-54-4]
UNSPSC
12352005
Target
Akt
Type
Reference compound
Related Pathways
PI3K/Akt/mTOR
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/akt-in-6.html
Purity
99.08
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
N#CC1=C(C2=CC3=C(C(N([C@@H](CC4=CC=CC(F)=C4)CN)C3)=O)C=C2)N(C)N=C1
Molecular Formula
C22H20FN5O
Molecular Weight
389.43
References & Citations
[1]Taisheng Huang; et al.Isoindolinone and pyrrolopyridinone derivatives as akt inhibitors. WO2013056015A1.|[2]Manning BD, et al. AKT/PKB signaling: navigating downstream. Cell. 2007;129 (7) :1261-1274.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Akt1; Akt2; Akt3
Available Sizes
Curated Selection
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