AT-0174
Product Specifications
UNSPSC Description
AT-0174 is an orally active dual inhibitor of IDO1/TDO2 (tryptophan 2,3-dioxygenase-2) with IC50 values of 0.17 and 0.25 μM, respectively. AT-0174 has antitumor activity[1][2].
Target Antigen
Indoleamine 2,3-Dioxygenase (IDO)
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/at-0174.html
Solubility
10 mM in DMSO
Smiles
NC1NOC2=NC(Cl)=C(F)C=C21
Molecular Weight
189.57
References & Citations
[1]Crump LS, et al. Targeting tryptophan catabolism in ovarian cancer to attenuate macrophage infiltration and PD-L1 expression. Cancer Res Commun. 2024 Mar 7.|[2]Crump LS, et al. Targeting tryptophan catabolism in ovarian cancer to attenuate macrophage infiltration and PD-L1 expression. Cancer Res Commun. 2024 Mar 7.|[3]Wu C, et al. Dual inhibition of IDO1/TDO2 enhances anti-tumor immunity in platinum-resistant non-small cell lung cancer. Cancer Metab. 2023 May 24;11(1):7.
Shipping Conditions
Room temperature
Clinical Information
No Development Reported
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