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MMP408

MMP408 is a potent and selective MMP-12 inhibitor that is derived from a potent matrix metalloprotease-2 and -13 inhibitor via lead optimization. MMP408 can block rhMMP-12-induced lung inflammation in vivo. MMP408 can be studied in research on COPD[1].

Product Specifications

CAS Number

[1025716-81-7]

UNSPSC

12352005

Target

MMP

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Field of Research

Inflammation/Immunology; Others

Assay Protocol

https://www.medchemexpress.com/mmp408.html

Purity

99.81

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

CC(C)[C@@H](C(O)=O)NS(=O)(C1=CC=C2C(OC3=CC=C(NC(OC)=O)C=C23)=C1)=O

Molecular Formula

C19H20N2O7S

Molecular Weight

420.44

References & Citations

[1]Li, W., et al., A selective matrix metalloprotease 12 inhibitor for potential treatment of chronic obstructive pulmonary disease (COPD) : discovery of (S) -2- (8- (methoxycarbonylamino) dibenzo[b, d]furan-3-sulfonamido) -3-methylbutanoic acid (MMP408) . Journal of medicinal chemistry, 52 (7), 1799–1802.

Shipping Conditions

Blue Ice

Storage Conditions

-20°C, 3 years (Powder)

Product Datasheet

http://file.medchemexpress.com/batch_PDF/HY-12093/MMP408-DataSheet-MedChemExpress.pdf

Product MSDS

http://file.medchemexpress.com/batch_PDF/HY-12093/MMP408-SDS-MedChemExpress.pdf

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Curated Selection

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