MMP408
MMP408 is a potent and selective MMP-12 inhibitor that is derived from a potent matrix metalloprotease-2 and -13 inhibitor via lead optimization. MMP408 can block rhMMP-12-induced lung inflammation in vivo. MMP408 can be studied in research on COPD[1].
Product Specifications
CAS Number
[1025716-81-7]
UNSPSC
12352005
Target
MMP
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Inflammation/Immunology; Others
Assay Protocol
https://www.medchemexpress.com/mmp408.html
Purity
99.81
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
CC(C)[C@@H](C(O)=O)NS(=O)(C1=CC=C2C(OC3=CC=C(NC(OC)=O)C=C23)=C1)=O
Molecular Formula
C19H20N2O7S
Molecular Weight
420.44
References & Citations
[1]Li, W., et al., A selective matrix metalloprotease 12 inhibitor for potential treatment of chronic obstructive pulmonary disease (COPD) : discovery of (S) -2- (8- (methoxycarbonylamino) dibenzo[b, d]furan-3-sulfonamido) -3-methylbutanoic acid (MMP408) . Journal of medicinal chemistry, 52 (7), 1799–1802.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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