Human CellExp™ SARS-CoV-2 Spike RBD (K417N, E484K, N501Y)

SARS-CoV-2 Spike protein is a large type I transmembrane protein composed of S1 subunit and S2 subunit. During viral infection, the receptor-binding domain (RBD) of the S1 subunit is responsible for the recognition and binding of host receptor ACE2, while the S2 subunit mediates viral cell membrane fusion. The SARS-CoV-2-S1-RBD/ACE2 interaction mediates viral entry into the target cells. The 501Y.V2 variant or lineage B.1.351 was first detected in South Africa. The variant contains three spike receptor binding site mutations (K417N, E484K and N501Y) that have been shown to mildly increase receptor binding.