΁EConotoxin GVIA

<strong>ρEConotoxin GVIA</strong> <strong>Catalog number:</strong> MDP0540 <strong>CAS Number: </strong>114547-31-8 <strong>Sequence: </strong>Cys-Lys-Ser-Hyp-Gly-Ser-Ser-Cys-Ser-Hyp-Thr-Ser-Tyr-Asn-Cys-Cys-Arg-Ser-Cys-Asn-Hyp-Tyr-Thr-Lys-Arg-Cys-Tyr-NH2 (Disulfide bonds between Cys1-Cys16, Cys8-Cys19, and Cys15-Cys26) <strong>Amount:</strong> 500 ug <strong>Molecular Weight:</strong> 3037.2 g/mol <strong>Supplied as:</strong> Powder <strong>Applications:</strong> molecular tool for various biochemical applications <strong>Storage:</strong> -20 °C <strong>WARNING:</strong> For in vitro Research Use Only. NOT for use on humans or animals. <strong>Grade:</strong> Biotechnology grade. All products are highly pure. <strong>References:</strong> 1: Yahagi N, Akiyama T, Yamazaki T. Effects of omega-conotoxin GVIA on cardiac sympathetic nerve function J Auton Nerv Syst. 1998 Jan 19;68(1-2):43-8. 2: Tranberg CE, Yang A, Vetter I, McArthur JR, Baell JB, Lewis RJ, Tuck KL, Duggan PJ. ω-Conotoxin GVIA mimetics that bind and inhibit neuronal Ca(v)2.2 ion channels Mar Drugs. 2012 Oct;10(10):2349-2368. 3: Yarotskyy V, Elmslie KS. omega-conotoxin GVIA alters gating charge movement of N-type (CaV2.2) calcium channels J Neurophysiol. 2009 Jan;101(1):332-40. 4: Oliveira CR, Agostinho P, Caseiro P, Duarte CB, Carvalho AP. Reactive oxygen species on GABA release Ann N Y Acad Sci. 1994 Nov 17;738:130-40. 5: Magrioti V, Nikolaou A, Smyrniotou A, Shah I, Constantinou-Kokotou V, Dennis EA, Kokotos G. New potent and selective polyfluoroalkyl ketone inhibitors of GVIA calcium-independent phospholipase A2 Bioorg Med Chem. 2013 Sep 15;21(18):5823-9. 6: Tringham EW, Dupere JR, Payne CE, Usowicz MM. Protease treatment of cerebellar purkinje cells renders omega-agatoxin IVA-sensitive Ca2+ channels insensitive to inhibition by omega-conotoxin GVIA J Pharmacol Exp Ther. 2008 Feb;324(2):806-14. 7: Gowd KH, Blais KD, Elmslie KS, Steiner AM, Olivera BM, Bulaj G. Dissecting a role of evolutionary-conserved but noncritical disulfide bridges in cysteine-rich peptides using ω-conotoxin GVIA and its selenocysteine analogs Biopolymers. 2012;98(3):212-23. 8: Glaum SR, Miller RJ. Presynaptic metabotropic glutamate receptors modulate omega-conotoxin-GVIA-insensitive calcium channels in the rat medulla Neuropharmacology. 1995 Aug;34(8):953-64. 9: Baell JB, Forsyth SA, Gable RW, Norton RS, Mulder RJ. Design and synthesis of type-III mimetics of omega-conotoxin GVIA J Comput Aided Mol Des. 2001 Dec;15(12):1119-36. <a href="https://pubmed.ncbi.nlm.nih.gov/19362476">10: Duggan PJ, Lewis RJ, Phei Lok Y, Lumsden NG, Tuck KL, Yang A. Low molecular weight non-peptide mimics of omega-conotoxin GVIA Bioorg Med Chem Lett. 2009 May 15;19(10):2763-5. </a> <br><strong>Products Related to ρEConotoxin GVIA can be found at</strong> <a href="https://moleculardepot.com/product-category/Peptides/"> Peptides</a>