SB-706375
SB-706375 is an antagonist of the Urotensin II (UII) receptor. By blocking the Urotensin II receptor, SB-706375 reduces the kidney's response to UII and Urotensin-related peptide (URP) and significantly increases the Glomerular Filtration Rate (GFR) . SB-706375 can be used in research on kidney diseases and hypertension[1].
Product Specifications
CAS Number
[733734-61-7]
UNSPSC
12352005
Target
Urotensin Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease; Others
Assay Protocol
https://www.medchemexpress.com/sb-706375.html
Concentration
10mM
Purity
99.08
Solubility
DMSO : 125 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=S(NC1=CC(O[C@H]2CN(C)CC2)=C(C(F)(F)F)C=C1)(C3=CC(OC)=C(OC)C=C3Br)=O
Molecular Formula
C20H22BrF3N2O5S
Molecular Weight
539.36
References & Citations
[1]Forty E J, et al. The urotensin system is up-regulated in the pre-hypertensive spontaneously hypertensive rat[J]. PLoS One, 2013, 8 (12) : e83317.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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