TC13172

TC13172 is a mixed lineage kinase domain-like protein (MLKL) inhibitor with an EC50 value of 2 nM for HT-29 cells[1].

Product Specifications

CAS Number

[2093393-05-4]

UNSPSC

12352005

Hazard Statement

H315, H319, H335

Target

Mixed Lineage Kinase

Type

Reference compound

Related Pathways

MAPK/ERK Pathway

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/TC13172.html

Purity

99.04

Solubility

DMSO : 25 mg/mL (ultrasonic)

Smiles

O=C1C2=C(N=C(S(C)(=O)=O)N2C)N(CC#CC3=CC(O)=CC=C3)C(N1C)=O

Molecular Formula

C17H16N4O5S

Molecular Weight

388.40

Precautions

H315, H319, H335

References & Citations

[1]Bo Yan, et al. Discovery of a new class of highly potent necroptosis inhibitors targeting the mixed lineage kinase domain-like protein.ChemCommun (Camb) . 2017 Mar 28;53 (26) :3637-3640.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Curated Selection

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