Brr2-IN-3
Brr2-IN-3 is a potent and selective Brr2 helicase allosteric Inhibitor. Brr2-IN-3 inhibits helicase activity in dose-dependent manner with an IC50 value of 1.3 μM[1].
Product Specifications
CAS Number
[2104030-82-0]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
DNA/RNA Synthesis
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/brr2-in-3.html
Concentration
10mM
Purity
99.66
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
O=C1NC(C(CN1C2=CC=CC(OCC3=CN=CS3)=C2)=CN4CC5=CC=CC=C5)=CC4=O
Molecular Formula
C24H20N4O3S
Molecular Weight
444.51
Precautions
H302, H315, H319, H335
References & Citations
[1]Iwatani-Yoshihara M, et al. Discovery of Allosteric Inhibitors Targeting the Spliceosomal RNA Helicase Brr2. J Med Chem. 2017;60 (13) :5759-5771.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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