hCA/VEGFR-2-IN-5
Product Specifications
UNSPSC Description
hCA/VEGFR-2 IN-5 (compound 9) is an indolone-phenylsulfonamide and a potential dual inhibitor of cancer-related hCA IX/XII and VEGFR-2. The IC50 values of hCA/VEGFR-2-IN-5 for VEGFR-2, hCA IX and hCA XII are 0.38 μM, 40 and 3.2 nM, respectively. hCA/VEGFR-2-IN-5 has antitumor activity[1].
Target Antigen
Carbonic Anhydrase; VEGFR
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease;Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/hca-vegfr-2-in-5.html
Smiles
O=S(C1=CC=C(N2N=NC(CO[C@H]3[C@@H]([C@H]([C@@H](CO3)OC(C)=O)OC(C)=O)OC(C)=O)=C2)C=C1)(NC4CCCCC4)=O
Molecular Weight
594.63
References & Citations
[1]Abbas HS, et al. New sulfonamide-based glycosides incorporated 1,2,3-triazole as cytotoxic agents through VEGFR-2 and carbonic anhydrase inhibitory activity. Sci Rep. 2024 Jun 6;14(1):13028.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-163710/hCA-VEGFR-2-IN-5-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-163710/
Clinical Information
No Development Reported
Curated Selection
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