HCA/VEGFR-2-IN-5

HCA/VEGFR-2 IN-5 (compound 9) is an indolone-phenylsulfonamide and a potential dual inhibitor of cancer-related hCA IX/XII and VEGFR-2. The IC50 values of hCA/VEGFR-2-IN-5 for VEGFR-2, hCA IX and hCA XII are 0.38 μM, 40 and 3.2 nM, respectively. hCA/VEGFR-2-IN-5 has antitumor activity[1].

Product Specifications

UNSPSC

12352005

Target

Carbonic Anhydrase; VEGFR

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease; Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/hca-vegfr-2-in-5.html

Smiles

O=S(C1=CC=C(N2N=NC(CO[C@H]3[C@@H]([C@H]([C@@H](CO3)OC(C)=O)OC(C)=O)OC(C)=O)=C2)C=C1)(NC4CCCCC4)=O

Molecular Formula

C26H34N4O10S

Molecular Weight

594.63

References & Citations

[1]Abbas HS, et al. New sulfonamide-based glycosides incorporated 1,2,3-triazole as cytotoxic agents through VEGFR-2 and carbonic anhydrase inhibitory activity. Sci Rep. 2024 Jun 6;14 (1) :13028.