PDE4B/D-IN-4

PDE4B/D-IN-4 (compound 4p) is a potent inhibitor of PDE-4B and PDE-4D, with IC50s of 5.50 nM and 6.81 nM, respectively. PDE4B/D-IN-4 shows an increase in the level of intracellular cAMP[1].

Product Specifications

UNSPSC

12352211

Target

Phosphodiesterase (PDE)

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/pde4b-d-in-4.html

Smiles

O=C(N/N=C/C1=CC=C(OC)C(O)=C1)C2=CC=C(OC(F)F)C(OCC3CC3)=C2

Molecular Formula

C20H20F2N2O5

Molecular Weight

406.38

References & Citations

[1]Ahmed M Moussa, et al. Rationale design and synthesis of new roflumilast analogues as preferential selective and potent PDE-4B inhibitors. Bioorg Chem. 2024 Oct 24:153:107911