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Amisulpride

Amisulpride ((Rac) -Aramisulpride) is a racemic (50:50) mixture of the R-Amisulpride and S-Amisulpride (HY-126068). Amisulpride is a dopamine D2/D3 receptor antagonist with Ki values of 2.8 and 3.2 nM for human dopamine b>D2 and b>D3, respectively. Amisulpride is a 5-HT7 receptor antagonist with a Ki of 44 nM. Amisulpride can be used in psychiatric research[1][2][3].

Product Specifications

CAS Number

71675-85-9

Product Name Alternative

(Rac) -Aramisulpride; (Rac) -Esamisulpride; DAN 2163

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

5-HT Receptor; Dopamine Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Cancer-programmed cell death

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/Amisulpride.html

Purity

99.81

Solubility

DMSO : 50 mg/mL (ultrasonic) |H2O : 0.2 mg/mL (ultrasonic)

Smiles

CCN1C(CNC(C2=CC(S(=O)(CC)=O)=C(N)C=C2OC)=O)CCC1

Molecular Formula

C17H27N3O4S

Molecular Weight

369.48

Precautions

H302, H315, H319, H335

References & Citations

[1]Schoemaker H, et al. Neurochemical characteristics of amisulpride, an atypical dopamine D2/D3 receptor antagonist with both presynaptic and limbic selectivity. 
 J Pharmacol Exp Ther. 1997 Jan;280 (1) :83-97.|[2]Pawar GR, et al. Evaluation of antidepressant like property of amisulpride per se and its comparison with fluoxetine and olanzapine using forced swimming test in albino mice. Acta Pol Pharm. 2009 May-Jun;66 (3) :327-31.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

Launched

Isoform

5-HT7 Receptor; D2 Receptor; D3 Receptor

Available Sizes

Frequently Asked Questions

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