SJ572403
SJ572403 (SJ403) is a p27Kip1 inhibitor. SJ572403 has high specificity for specific regions within the D2 subdomain of p27-KID with a Kd value of 2.2 mM. SJ572403 can be used for the research of diseases associated with intrinsically disordered proteins (IDPs) [1].
Product Specifications
CAS Number
19970-45-7
Product Name Alternative
SJ403
UNSPSC
12352005
Target
CDK
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/SJ572403.html
Concentration
10mM
Purity
98.92
Solubility
DMSO : 13.89 mg/mL (ultrasonic)
Smiles
O=C(N(C1=C(C2=O)N3C(N(C(C)=C3C)CC)=N1)C)N2C
Molecular Formula
C13H17N5O2
Molecular Weight
275.31
References & Citations
[1]Iconaru LI, et al. Discovery of Small Molecules that Inhibit the Disordered Protein, p27 (Kip1) . Sci Rep. 2015 Oct 28;5:15686.|[2]Pablo Herrera-Nieto, et al. Small Molecule Modulation of Intrinsically Disordered Proteins Using Molecular Dynamics Simulations. J Chem Inf Model. 2020 Oct 26;60 (10) :5003-5010.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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