SJ572403

SJ572403 (SJ403) is a p27Kip1 inhibitor. SJ572403 has high specificity for specific regions within the D2 subdomain of p27-KID with a Kd value of 2.2 mM. SJ572403 can be used for the research of diseases associated with intrinsically disordered proteins (IDPs) [1].

Product Specifications

CAS Number

[19970-45-7]

Product Name Alternative

SJ403

UNSPSC

12352005

Target

CDK

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage

Applications

Cancer-programmed cell death

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/SJ572403.html

Concentration

10mM

Purity

98.92

Solubility

DMSO : 13.89 mg/mL (ultrasonic)

Smiles

O=C(N(C1=C(C2=O)N3C(N(C(C)=C3C)CC)=N1)C)N2C

Molecular Formula

C13H17N5O2

Molecular Weight

275.31

References & Citations

[1]Iconaru LI, et al. Discovery of Small Molecules that Inhibit the Disordered Protein, p27 (Kip1) . Sci Rep. 2015 Oct 28;5:15686.|[2]Pablo Herrera-Nieto, et al. Small Molecule Modulation of Intrinsically Disordered Proteins Using Molecular Dynamics Simulations. J Chem Inf Model. 2020 Oct 26;60 (10) :5003-5010.