Naloxone HCl
Opioid Receptor Antagonist
Product Specifications
Background
Pan-opioid receptor antagonist (1). In clinical use in opiate abuse and overdose rescue (2). Blocks opiate- promoted wound healing (3). Attenuates the pruritic response to rimonabant in a rat model (4).
CAS Number
357-08-4
Product Name Alternative
5α) -4,5-Epoxy-3,14-dihydro-17- (2-propenyl) morphinan-6-one, hydrochloride
UNSPSC
41116105
Type
Antagonist
Source
Synthetic
Purity
>98% (HPLC) ; NMR (Conforms)
Weight
0.005
Format
White crystalline powder
Solubility
May be dissolved in DMSO (35 mg/ml); water (30 mg/ml)
Molecular Formula
C19H21NO4 • HCl
Molecular Weight
363.8
Precautions
Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
References & Citations
1. Le Bourdonnec B.,et al. (2008)Bioorg. Med. Chem. Lett. 18:2006.
2. EW., Boyer (2012) New Engl. J. Med. 367:146.
3. WangY., et al. (2017) Transl. Res. 185:13.
4. Wright FL., and RJ Rodgers (2013) Psychopharmacology (Berl.) 226:415.
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