RGB-1
RGB-1 is a polycyclic aromatic hydrocarbon molecule and a stabilizer of RNA G-quadruplexes. RGB-1 can promote the inhibition of RNA translation and reduce the expression of NRAS proto-oncogene in breast cancer cells[1].
Product Specifications
CAS Number
[930455-91-7]
UNSPSC
12352005
Target
Ras
Type
Reference compound
Related Pathways
GPCR/G Protein; MAPK/ERK Pathway
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/rgb-1.html
Purity
98.07
Solubility
DMSO : < 1 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C1C2=C(SC=C2C3=CC=CO3)N=C4N1CC5=NC6=C(C(N5C4)=O)C(C7=CC=CO7)=CS6
Molecular Formula
C22H12N4O4S2
Molecular Weight
460.49
References & Citations
[1]Katsuda Y, et al. A Small Molecule That Represses Translation of G-Quadruplex-Containing mRNA. J Am Chem Soc. 2016 Jul 27;138 (29) :9037-40.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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