Phospho-Stat5 (Tyr694) Rabbit PE Conjugate

<strong>Phospho-Stat5 (Tyr694) Rabbit PE Conjugate</strong>_x000D_ <strong>Catalog number:</strong> B2018649_x000D_ <strong>Lot number:</strong> Batch Dependent_x000D_ <strong>Expiration Date:</strong> Batch dependent_x000D_ <strong>Amount:</strong> 10 ug_x000D_ <strong>Molecular Weight or Concentration:</strong> N/A_x000D_ <strong>Supplied as:</strong> Solution_x000D_ <strong>Applications:</strong> a molecular tool for various biochemical applications_x000D_ <strong>Storage:</strong> 2-8°C_x000D_ <strong>Keywords:</strong> Signal transducer and activator of transcription 5A, STAT5A, Signal transducer and activator of transcription 5B, STAT5B_x000D_ <strong>Grade:</strong> Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity &gt;18 MΩ-cm) and are filtered through 0.22 um._x000D_ _x000D_ <strong>References:</strong>_x000D_ 1: Beuvink I, Hess D, Flotow H, Hofsteenge J, Groner B, Hynes NE. Stat5a serine phosphorylation. Serine 779 is constitutively phosphorylated in the mammary gland, and serine 725 phosphorylation influences prolactin-stimulated in vitro DNA binding activity J Biol Chem. 2000 Apr 7;275(14):10247-55._x000D_ 2: Gouilleux F, Wakao H, Mundt M, Groner B. Prolactin induces phosphorylation of Tyr694 of Stat5 (MGF), a prerequisite for DNA binding and induction of transcription EMBO J. 1994 Sep 15;13(18):4361-9._x000D_ 3: Altwaijry N, Sabour R, Ibrahim MH, Al Kamaly O, Abdullah O, Harras MF. Design, synthesis, and anti-hepatocellular carcinoma of thiopyrimidine/chalcone hybrids as dual STAT3/STAT5 inhibitors RSC Med Chem. 2023 Aug 15;14(10):1981-1991._x000D_ 4: Spohn L, Fichter C, Werner M, Lassmann S. Subcellular localization of EGFR in esophageal carcinoma cell lines J Cell Commun Signal. 2016 Mar;10(1):41-7._x000D_ 5: Adach A, Ellert-Miklaszewska A, Kaminska B. Molecular characterization of STAT signaling in inflammation and tumorigenesis Methods Mol Biol. 2009;512:265-78._x000D_ 6: Zhao WL, Xing Y, Ye C, Qiu YH, Li Y, Liu XJ, Wang MY, Bi CW, Song DQ, Shao RG. The novel quinolizidine derivate IMB-HDC inhibits STAT5a phosphorylation at 694 and 780 and promotes DNA breakage and cell apoptosis via blocking STAT5a nuclear translocation Acta Pharmacol Sin. 2020 May;41(5):686-697._x000D_ 7: Olayioye MA, Beuvink I, Horsch K, Daly JM, Hynes NE. ErbB receptor-induced activation of stat transcription factors is mediated by Src tyrosine kinases J Biol Chem. 1999 Jun 11;274(24):17209-18._x000D_ 8: Chang M, Kanwar N, Feng E, Siu A, Liu X, Ma D, Jongstra J. PIM kinase inhibitors downregulate STAT3(Tyr705) phosphorylation Mol Cancer Ther. 2010 Sep;9(9):2478-87._x000D_ 9: Sun Y, Cheng MK, Griffiths TR, Mellon JK, Kai B, Kriajevska M, Manson MM. Inhibition of STAT signalling in bladder cancer by diindolylmethane: relevance to cell adhesion, migration and proliferation Curr Cancer Drug Targets. 2013 Jan;13(1):57-68._x000D_ <a href="https://pubmed.ncbi.nlm.nih.gov/15536163">10: Tiulpakov A, Rubtsov P, Dedov I, Peterkova V, Bezlepkina O, Chrousos GP, Hochberg Z. A novel C-terminal growth hormone receptor (GHR) mutation results in impaired GHR-STAT5 but normal STAT-3 signaling J Clin Endocrinol Metab. 2005 Jan;90(1):542-7. </a>_x000D_ _x000D_ <strong>Products Related to Phospho-Stat5 (Tyr694) Rabbit PE Conjugate can be found at</strong> <a href="https://moleculardepot.com/product-category/Proteins/"> Proteins</a>