PF-4455242 (hydrochloride)

PF-4455242 hydrochloride is a selective, short-acting antagonist of the κ-opioid receptor, exhibiting potential analgesic effects. PF-4455242 hydrochloride has been identified through a strategy utilizing parallel chemistry and physicochemical property design. PF-4455242 hydrochloride demonstrated confirmed potency and selectivity in the tail-flick analgesia model.

Product Specifications

CAS Number

[1322001-35-3]

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

Opioid Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/pf-4455242-hydrochloride.html

Smiles

O=S(C1=CC=CC=C1C2=CC=C(CNCC(C)C)C=C2)(N3CCCC3)=O.Cl

Molecular Formula

C21H29ClN2O2S

Molecular Weight

408.99

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

References & Citations

[1]Design and discovery of a selective small molecule κ opioid antagonist (2-methyl-N- ((2'- (pyrrolidin-1-ylsulfonyl) biphenyl-4-yl) methyl) propan-1-amine, PF-4455242)